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Chapter 35: Cognitive Dysfunction in Dogs References


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Landsberg G, Araujo JA. Behavior problems in geriatric pets. Veterinary Clinics of North America: Small Animal Practice 2005; 35: 675-698.

Landsberg G, Hunthausen W, Ackerman L. The effects of aging on behavior in senior pets. Handbook of Behavior Problems of the Dog and Cat. Edinburgh, Scotland: Elsevier Health Sciences, 2003.

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Milgram NW, Head E, Weiner E, et al. Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks. Behavioral Neuroscience 1994; 108: 57-68.

Milgram NW, Head E, Zicker SC, et al. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: A two-year longitudinal study. Neurobiology of Aging 2005; 26: 77-90.

Milgram NW, Head E, Zicker SC, et al. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental Gerontology 2004; 39: 753-765.

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Siwak CT, Tapp PD, Milgram NW. Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learning and Memory 2001; 8: 317-325.

Siwak CT, Tapp PD, Zicker SC, et al. Locomotor activity rhythms in dogs vary with age and cognitive status. Behavioral Neuroscience 2003; 117: 813-824.

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Tapp PD, Siwak CT, Estrada J, et al. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learning and Memory 2003; 10: 64-73.

Tapp PD, Siwak CT, Gao FQ, et al. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. Journal of Neuroscience 2004; 24: 8205-8213.

Tapp PD, Siwak CT, Head E, et al. Concept abstraction in the aging dog: Development of a protocol using successive discrimination and size concept tasks. Behavioural Brain Research 2004a; 153: 199-210.

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Zicker SC. Cognitive and behavioral assessment in dogs and pet food market applications. Progress in Neuropsychopharmacology and Biological Psychiatry 2005; 29: 455-459.



Box 35-1 Bibliography

Brellou G, Vlemmas I, Lekkas S, et al. Immunohistochemical investigation of amyloid beta-protein (Abeta) in the brain of aged cats. Histology and Histopathology 2005; 20: 725-731.

Cummings BJ, Satou T, Head E, et al. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: Evidence from cats and dogs. Neurobiology of Aging 1996; 17: 653-659.

Head E, Moffat K, Das P, et al. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging 2005; 26: 749-763.

Hill’s Pet Nutrition, Inc., Omnibus Study on Aging Pets. U.S. Marketing Research Summary, 2000.

Landsberg G, Araujo JA. Behavior problems in geriatric pets. Veterinary Clinics of North America: Small Animal Practice 2005; 35: 675-698.

Landsberg G, Hunthausen W, Ackerman L. The effects of aging on behavior in senior pets. Handbook of Behavior Problems of the Dog and Cat. Edinburgh, Scotland: Elsevier Health Sciences, 2003.

Landsberg G. The most common behavior problems in older dogs. Veterinary Medicine 1995; 90: 16-24.

Moffat K, Landsberg G. An investigation into the prevalence of clinical signs of cognitive dysfunction syndrome (CDS) in cats. Journal of the American Animal Hospital Association 2003; 39: 512.

Nakamura S, Nakayama H, Kiatipattanasakul W, et al. Senile plaques in very aged cats. Acta Neuropathologica (Berlin) 1996; 91: 437-439.



Box 35-2 Bibliography

Araujo JA, Milgram NW. A novel cognitive palatability assessment protocol for dogs. Journal of Animal Science 2004; 82: 2200-2206.

Milgram NW, Head E, Weiner E, et al. Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks. Behavioral Neuroscience 1994; 108: 57-68.



Box 35-3 Bibliography

Adams B, Chan A, Callahan H, et al. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behavioural Brain Research 2000; 108: 47-56.

Cummings BJ, Head E, Afagh AJ, et al. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiology of Learning and Memory 1996; 66: 11-23.

Cummings BJ, Head E, Ruehl W, et al. The canine as an animal model of human aging and dementia. Neurobiology of Aging 1996; 17: 259-268.

Head E, Callahan H, Muggenburg BA, et al. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiology of Aging 1998; 19: 415-425.

Head E, Mehta R, Hartley J, et al. Spatial learning and memory as a function of age in the dog. Behavioral Neuroscience 1995; 109: 851-858.

Milgram NW, Head E, Weiner E, et al. Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks. Behavioral Neuroscience 1994; 108: 57-68.

Su MY, Head E, Brooks WM, et al. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiology of Aging 1998; 19: 479-485.

Tapp PD, Siwak CT, Gao FQ, et al. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. Journal of Neuroscience 2004; 24: 8205-8213.






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