Small Animal Clinical Nutrition

The most comprehensive and practical small animal nutrition resource available.

Chapter 29: Endocrine Disorders References


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Barsanti JA, Jones BD, Spano JS, et al. Prolonged anorexia associated with hepatic lipidosis in three cats. Feline Practice 1977; 7: 52-57.

Bennett N, Greco DS, Peterson ME, et al. Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus. Journal of Feline Medicine and Surgery 2006; 8: 73-84.

Broussard JD, Peterson ME, Fox PR. Changes in clinical and laboratory findings in cats with hyperthyroidism from 1983-1993. Journal of the American Veterinary Medical Association 1995; 206: 302-305.

Chandalia M, Garg A, Lutjohann D, et al. Beneficial effect of high dietary fiber intake in patients with type 2 diabetes mellitus. New England Journal of Medicine 2000; 342: 1392-1398.

Conaway DH, Padgett GA, Bunton TE, et al. Clinical and histological features of primary progressive, familial thyroiditis in a colony of borzoi dogs. Veterinary Pathology 1985; 22: 439-446.

Court MH, Freeman LM. Identification and concentration of soy isoflavones in commercial cat foods. American Journal of Veterinary Research 2002; 63: 181-185.

Crenshaw KL, Peterson ME, Heeb LA, et al. Serum fructosamine concentration as an index of glycemia in cats with diabetes mellitus and stress hyperglycemia. Journal of Veterinary Internal Medicine 1996; 10: 360-364.

Crenshaw KL, Peterson ME. Pretreatment clinical and laboratory evaluation of cats with diabetes mellitus: 104 cases (1992-1994). Journal of the American Veterinary Medical Association 1996; 209: 943-949.

Davey JC, Becker KB, Schneider MJ, et al. Cloning of a cDNA for the type II iodothyronine deiodinase. Journal of Biological Chemistry 1995; 270: 26786-26789.

DeBowes LJ. Lipid metabolism and hyperlipoproteinemia in dogs. Compendium on Continuing Education for the Practicing Veterinarian 1987; 9: 727.

Divi RL, Chang HC, Doerge DR. Anti-thyroid isoflavones from soybean: Isolation, characterization, and mechanisms of action. Biochemical Pharmacology 1997; 54: 1087-1096.

Edinboro CH, Scott-Moncrieff JC, Janovitz E, et al. Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats. Journal of the American Veterinary Medical Association 2004; 224: 879-886.

Elliott DA, Nelson RW, Reusch CE, et al. Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetes mellitus. Journal of the American Veterinary Medical Association 1999; 214: 1794-1798.

Farrow HA, Rand JS, Sunvold GD. Diets high in protein are associated with lower postprandial glucose and insulin concentrations than diets high in either fat or carbohydrate in normal cats. Journal of Veterinary Internal Medicine 2002; 16: 360.

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Feldman EC, Nelson RW, eds. Feline hyperthyroidism (thyrotoxicosis). In: Canine and Feline Endocrinology and Reproduction, 3rd ed. Philadelphia, PA: WB Saunders Co, 2004e; 152-218.

Feldman EC, Nelson RW, eds. Hypothyroidism. In: Canine and Feline Endocrinology and Reproduction, 3rd ed. Philadelphia, PA: WB Saunders Co, 2004c; 86-151.

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Frank G, Anderson W, Pazak H, et al. Use of a high-protein diet in the management of feline diabetes mellitus. Veterinary Therapeutics 2001; 2: 238-246.

Freake HC, Oppenheimer JH. Thermogenesis and thyroid function. Annual Review of Nutrition 1995; 15: 263-291.

Gerber H, Peter H, Ferguson DC, et al. Etiopathology of feline toxic nodular goiter. Veterinary Clinics of North America: Small Animal Practice 1994; 24: 541-565.

Goossens M, Nelson RW, Feldman EC. Response to insulin treatment and survival in 104 cats with diabetes mellitus (1985-1995). Journal of Veterinary Internal Medicine 1998; 12: 1-6.

Gosselin SJ, Capen CC, Martin SL. Histopathologic and ultrastructural evaluation of thyroid lesions associated with hypothyroidism in dogs. Veterinary Pathology 1981; 18: 299-309.

Graham PA, Maskell IE, Nash AS. Canned high fiber diet and postprandial glycemia in dogs with naturally occurring diabetes mellitus. Journal of Nutrition 1994; 124: 2712S-2715S.

Graham PA, Maskell IE, Rawlings JM, et al. Influence of a high fibre diet on glycaemic control and quality of life in dogs with diabetes mellitus. Journal of Small Animal Practice 2002; 43: 67-73.

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Greco DS, Rosychuk RA, Ogilvie GK, et al. The effect of levothyroxine treatment on resting energy expenditure of hypothyroid dogs. Journal of Veterinary Internal Medicine 1998; 12: 7-10.

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Haines DM. A re-examination of islet cell cytoplasmic antibodies in diabetic dogs. Veterinary Immunology and Immunopathology 1986; 11: 225-233.

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Hess RS, Kass PH, Van Winkle TJ. Association between diabetes mellitus, hypothyroidism or hyperadrenocorticism, and atherosclerosis in dogs. Journal of Veterinary Internal Medicine 2003; 17: 489-494.

Hess RS, Kass PH, Ward CR. Breed distribution of dogs with diabetes mellitus admitted to a tertiary care facility. Journal of the American Veterinary Medical Association 2000; 216: 1414-1417.

Hiddinga HJ , Eberhardt NL. Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells. American Journal of Pathology 1999; 154(4): 1077-1088.

Hoenig M, Dawe DL. A qualitative assay for beta cell antibodies. Preliminary results in dogs with diabetes mellitus. Veterinary Immunology and Immunopathology 1992; 32: 195-203.

Hoenig M, Tomaseth K, Waldron M, et al. Insulin sensitive, fat distribution, and adipocytokine response to different diets in lean, and obese cats before and after weight loss. The American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology, 2006 (online).

Hoenig M. Comparative aspects of diabetes mellitus in dogs and cats. Molecular and Cellular Endocrinology 2002; 197: 221-229.

Holzworth J, Theran P, Carpenter JL. Hyperthyroidism in the cat: Ten cases. Journal of the American Veterinary Medical Association 1980; 46: 345-353.

Ihle SL. Nutritional therapy for diabetes mellitus. Veterinary Clinics of North America: Small Animal Practice 1995; 25: 585-597.

James DE, Brown R, Navarro J, et al. Insulin-regulatable tissues express a unique insulin sensitive glucose transport protein. Nature 1988; 333: 183-185.

Johnson KH, O’Brien TD, Betsholtz C, et al. Islet amyloid, islet amyloid polypeptide and diabetes mellitus. New England Journal of Medicine 1989; 321: 513-518. 

Johnson KH, O’Brien TD, Hayden DW, et al. Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells using peroxidase antiperoxidase (PAP) and protein A-gold techniques. American Journal of Pathology 1988; 130: 1-8.

Johnson LA, Ford HC, Tartellin MF, et al. Iodine content of commercially-prepared foods. New Zealand Veterinary Journal 1992; 40: 18-20.

Kang JH, Kondo F. Determination of bisphenol A in canned pet foods. Research in Veterinary Science 2002; 73: 177-182.

Kaptein EM, Hays MT, Ferguson DC. Thyroid hormone metabolism: A comparative evaluation. Veterinary Clinics of North America: Small Animal Practice 1994; 24: 431-463.

Kass PH, Peterson ME, Levy J, et al. Evaluation of environmental, nutritional, and host factors in cats with hyperthyroidism. Journal of Veterinary Internal Medicine 1999; 13: 323-329.

Kienzle E. Blood sugar levels and renal sugar extraction after the intake of high carbohydrate diets in cats. Journal of Nutrition 1994; 125: 2563S-2567S.

Kintzer PP. Considerations in the treatment of feline hyperthyroidism. Veterinary Clinics of North America: Small Animal Practice 1994; 24: 577-585.

Kirk CA, Feldman EC, Nelson RW. Diagnosis of naturally acquired type-I and type-II diabetes mellitus in cats. American Journal of Veterinary Research 1993; 54: 463-467.

Kirk CA. Feline diabetes mellitus: Low carbohydrates versus high fiber? Veterinary Clinics of North America: Small Animal Practice 2006; 36: 1297-1306.

Larsen PR, Berry MJ. Nutritional and hormonal regulation of thyroid deiodinases. Annual Review of Nutrition 1995; 15: 323-352.

Lutz TA, Rand JS, Ryan E. Fructosamine concentrations in hyperglycemic cats. Canadian Veterinary Journal 1995; 36: 155-159.

Lutz TA, Rand JS. Plasma amylin and insulin concentrations in normoglycemic and hyperglycemic cats. Canadian Veterinary Journal 1996; 37: 27-34.

Mahley RW, Weisgraber KH, Farese RV. Disorders of lipid metabolism. In: Larsen RP, Kronenberg HM, Melmed S, et al, eds. Williams Textbook of Endocrinology, 10th ed. Philadelphia, PA: WB Saunders Co, 2003; 1642-1705.

Martin BC, Warram JH, Krolewski AS, et al. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study. Lancet 1992; 340: 925.

Martin GW, Rand JS. Current understanding of feline diabetes: Part 2, treatment. Journal of Feline Medicine and Surgery 2000; 2(1): 3-17.

Martin KM, Rossing MA, Ryland LM, et al. Evaluation of dietary and environmental risk factors for hyperthyroidism in cats. Journal of the American Veterinary Medical Association 2000; 217: 853-856.

Masharani U, Karam JH. Pancreatic hormones and diabetes mellitus. In: Greenspan FS, Gardner DG, eds. Basic and Clinical Endocrinology, 6th ed. New York, NY: McGraw-Hill, 2001; 623-698.

Maskell IE, Graham P. Endocrine disorders. In: Wills JM, Simpson KW, eds. The Waltham Book of Clinical Nutrition of the Dog & Cat. Tarrytown, NY: Elsevier, 1994; 373-394.

Massillon D, Brazilai N, Hawkins M, et al. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes 1997; 46: 153-157.

Mazzaferro EM, Greco DS, Peterson ME, et al. Treatment of feline diabetes mellitus using an -glucosidase inhibitor and a low-carbohydrate diet. Journal of Feline Medicine and Surgery 2003; 5: 183-189.

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Muir HE, Murray SM, Fahey GC, et al. Nutrient digestion by ileal cannulated dogs as affected by dietary fibers with various fermentation characteristics. Journal of Animal Science 1996; 74: 1641-1648.

Mumma RO, Rashid KA, Shane BS, et al. Toxic and protective constituents in pet foods. American Journal of Veterinary Research 1986; 47: 1633-1637.

Nachreiner RF, Refsal KR, Graham PA, et al. Prevalence of serum thyroid hormone autoantibodies in dogs with clinical signs of hypothyroidism. Journal of the American Veterinary Medical Association 2002; 220: 466-471.

Nakayama H, Uchida K, Ono K, et al. Pathological observations in six cases of feline diabetes mellitus. Japanese Journal of Veterinary Science 1990; 52: 819-822. 

Nelson RW, Briggs C, Scott-Moncrieff JC, et al. Effect of dietary fiber type and quantity on control of glycemia in diabetic dogs. Journal of Veterinary Internal Medicine 2000a; 14(3): 376.

Nelson RW, Duesberg CA, Ford SL, et al. Effect of dietary insoluble fiber on control of glycemia in dogs with naturally acquired diabetes mellitus. Journal of the American Veterinary Medical Association 1998; 212: 380-386.

Nelson RW, Feldman EC, Ford SL, et al. Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats. Journal of the American Veterinary Medical Association 1993; 203: 821-827.

Nelson RW, Ihle SL, Lewis LD, et al. Effects of dietary fiber supplementation on glycemic control in dogs with alloxan induced diabetes mellitus. American Journal of Veterinary Research 1991; 52: 2060-2066.

Nelson RW, Scott-Moncrief JC, Feldman EC, et al. Effect of dietary insoluble fiber on control of glycemia in cats. Journal of the American Veterinary Medical Association 2000; 216: 1082-1088.

Nelson RW. Dietary therapy for diabetes mellitus. Compendium on Continuing Education for the Practicing Veterinarian 1988; 10: 1387-1392.

Nerup J, Mandrup-Poulson T, Helqvist S, et al. On the pathogenesis of IDDM. Diabetologia 1994; 37 (Suppl. 2): S82-S89.

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Nichols R, Crenshaw KL. Complications and concurrent disease associated with diabetic ketoacidosis and other severe forms of diabetes mellitus. Veterinary Clinics of North America: Small Animal Practice 1995; 25: 617-624.

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Peterson ME, Melian C, Nichols R. Measurement of serum concentrations of free thyroxine, total thyroxine, and total triiodothyronine in cats with hyperthyroidism and cats with nonthyroidal disease. Journal of the American Veterinary Medical Association 2001; 218: 529-536.

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Scarlett JM, Moise NS, Rayl J. Feline hyperthyroidism: A descriptive and case-control study. Preventive Veterinary Medicine 1988; 6: 295-309.

Scarlett JM. Epidemiology of thyroid disease of dogs and cats. Veterinary Clinics of North America: Small Animal Practice 1994; 24: 477-486.

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Zoran DL. The carnivore connection to nutrition in cats. Journal of the American Veterinary Medical Association 2002; 221: 1559-1567.



Box 29-1 Bibliography


Driscoll HK, Chertow BS, Jelic TM, et al. Vitamin A status affects the development of diabetes and insulitis in BB rats. Metabolism 1996; 45: 248-253.

Keen CL, Zidenberg-Cherr S. Manganese. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition, 7th ed. Washington, DC: ILSI Press, 1996; 334-343.

Mooradian AD, Morley JE. Micronutrient status in diabetes mellitus. American Journal of Clinical Nutrition 1987; 45: 877-895.

Nielson FH. Other trace elements. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition, 7th ed. Washington, DC: ILSI Press, 1996; 353-377.

Plotnick AN, Greco DS, Crans DS, et al. Oral vanadium compounds: Preliminary studies on toxicity in normal cats and hypoglycemic potential in diabetic cats (abstract). In: Proceedings. Thirteenth Annual Veterinary Medical Forum, American College of Veterinary Internal Medicine, Lake Buena Vista, FL, 1995: 996.

Stoecker BJ. Chromium. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition, 7th ed. Washington, DC: ILSI Press, 1996; 344-352.

Tuitoek PJ, Lakey JRT, Rajotte RV, et al. Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats. International Journal of Vitamin and Nutrition Research 1996; 66: 101-105.



Box 29-3 Bibliography

Brown RS, Keating P, Livingston PG, et al. Thyroid growth promoting immunoglobulins in feline hyperthyroidism. Thyroid 1992; 2: 125-130.

Combs GF Jr. Development of anti-carcinogenic foods from animals. In: Proceedings. 2000 Cornell Nutrition Conference for Feed Manufacturers, 62nd Meeting, October 2000: 40-45.

Court MH, Freeman LM. Identification and concentration of soy isoflavones in commercial cat foods. American Journal of Veterinary Research 2002; 63: 181-185.

Dietary Reference Intakes (DRI) for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington DC: National Academy Press, 2001; 314.

Edinboro CH, Scott-Moncrieff C, Janovitz E, et al. Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats. Journal of the American Veterinary Medical Association 2004; 224: 879-886.

Foster DJ, Thoday KL, Arthur JR, et al. Selenium status of cats in four regions of the world and comparison with reported incidence of hyperthyroidism in cats in those regions. American Journal of Veterinary Research 2001; 62: 934-937.

Holzworth J, Theran P, Carpenter JL, et al. Hyperthyroidism in the cat: Ten cases. Journal of the American Veterinary Medical Association 1980; 176: 345-353.

Johnson LA, Ford HC, Tartellin MF, et al. Iodine content of commercially-prepared cat foods. New Zealand Veterinary Journal 1992; 40: 18-20.

Kass PH, Peterson ME, Levy J, et al. Evaluation of environmental, nutritional, and host factors in cats with hyperthyroidism. Journal of Veterinary Internal Medicine 1999; 13: 323-329.

Kyle AHM, Tartellin MF, Cooke RR, et al. Serum free thyroxine levels in cats maintained on diets relatively high or low in iodine. New Zealand Veterinary Journal 1994; 42: 101-103.

Levander OA. Selenium. In: Mertz W, ed. Trace Elements in Human and Animal Nutrition. Orlando, FL: Academic Press Inc, 1986; 209-279.

Martin KM, Rossing MA, Ryland ML, et al. Evaluation of dietary and environmental risk factors for hyperthyroidism in cats. Journal of the American Veterinary Medical Association 2000; 217: 853-856.

Mumma RO, Rashid KA, Shane BS, et al. Toxic and protective constituents in pet foods. American Journal of Veterinary Research 1986; 47: 1633-1637.

Neve J. Selenium as a ‘nutraceutical’: How to conciliate physiological and supra-nutritional effects for an essential trace element. Current Opinion in Clinical Nutrition and Metabolic Care 2002; 5: 659-63.

Olczak J, Jones BR, Pfeiffer DU, et al. Multi-variate analysis of risk factors for feline hyperthyroidism in New Zealand. New Zealand Veterinary Journal 2005; 53: 53-58.

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Peterson ME, Becker DV, Hurley JR, et al. Spontaneous feline hyperthyroidism. In: Proceedings. The 62nd Annual Meeting of the Endocrine Society. Washington, DC, 1980: 203.

Peterson ME, Johnson GF, Andrews LK. Spontaneous hyperthyroidism in the cat. In: Proceedings. The American College of Veterinary Internal Medicine, 1979: 108.

Ranz D, Tetrick M, Opitz B, et al. Estimation of iodine status in cats. Journal of Nutrition 2002; 132: 1751S-1753S.

Scarlett JM, Moise NS, Rayl J. Feline hyperthyroidism: A descriptive and case-control study. Preventive Veterinary Medicine 1988; 6: 295-305.

Simcock SE, Rutherfurd SM, Hendriks WH. The role of selenium in companion animal health and nutrition. In: Lyons TP, Jacques KA, eds. Nutritional Biotechnology in the Feed and Food Industries: Proceedings of Alltech’s 18th Annual Symposium. Nottingham, UK: Nottingham University Press, 2002; 511-520.

Tartellin MF, Johnson LA, Cooke RR, et al. Serum free thyroxine levels respond inversely to changes in levels of dietary iodine in the domestic cat. New Zealand Veterinary Journal 1992; 40: 66-68.

Wedekind KJ, Howard KA, Backus RC, et al. Determination of selenium requirement in kittens. Journal of Animal Physiology and Animal Nutrition 2003; 87: 315-323.

Wedekind KJ, Yu S, Combs GF Jr. The selenium requirement of the puppy. Journal of Animal Physiology and Animal Nutrition 2004; 88: 340-347.

Yu S, Howard KA, Wedekind KJ, et al. A low-selenium diet increases thyroxine and decreases 3,5,3’ triiodothyronine in the plasma of kittens. Journal of Animal Physiology and Animal Nutrition 2002; 86: 36-41.



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